From the North:
Take I-95 South, go through the Fort McHenry Tunnel and take exit 53 -- 395 North/Downtown.  Bear right at the first light onto Conway Street. At the second traffic light, turn left onto Charles Street. Proceed to the corner of Charles and Fayette Streets. The JHU Downtown Center is on the left hand side.

OR

Take the Jones Falls Expressway South (I-83 South).  Follow the expressway to the first traffic light at Fayette Street. Make a right onto Fayette Street. Follow up to Charles Street. The center is on the left corner of Charles and Fayette Streets.

From the South:
Take I-95 North, take exit 53 -- 395 North/Downtown.  Bear right at the first light onto Conway Street. At the second traffic light, turn onto Charles Street. Proceed to the corner of Charles and Fayette Streets. The JHU Downtown Center is on the left hand side.

Parking:

St. Paul Plaza Garage: Enter the parking garage on Lexington between Charles and St. Paul Streets.  Exit parking garage on Lexington Street and proceed to Charles Street.  Walk south on Charles Street to the Downtown Center.

Two Charles Center Underground Garage: Enter the parking garage (the sign does not identify the garage as Two Charles Center -- the sign says "Parking")  OR enter the parking garage on Liberty Street (make the first left after Churchill's Restaurant -- sign says "Public Parking - 600 Spaces"  Use the garage elevators to access the Downtown Center.  Exit at the P level for the Berman Auditorium or the M level for the main reception area. 

Note: this garage does not have sufficient clearance to accommodate vans.